NF-κB, an Active Player in Human Cancers
نویسندگان
چکیده
منابع مشابه
NF-κB, an active player in human cancers.
NF-κB comprises a family of five transcription factors that form distinct protein complexes, which bind to consensus DNA sequences at promoter regions of responsive genes regulating cellular processes. The past three decades have witnessed remarkable progress in understanding the NF-κB signaling pathway in physiologic and pathologic conditions. The role of NF-κB in human cancer initiation, deve...
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Each of the IkB proteins contains six or more 33The inhibitory protein, IkBa, sequesters the transcripresidue-long ankyrin repeats, named for their homology tion factor, NF-kB, as an inactive complex in the cytoto repeats in the erythrocyte protein ankyrin (reviewed plasm. The structure of the IkBa ankyrin repeat domain, in Bork, 1993). Ankyrin, which has 24 such repeats, links bound to a parti...
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ژورنال
عنوان ژورنال: Cancer Immunology Research
سال: 2014
ISSN: 2326-6066,2326-6074
DOI: 10.1158/2326-6066.cir-14-0112